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Cancer metabolism: looking forward
Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …
Cancer cells autonomously alter their flux through various metabolic pathways in order to …
The metabolism of cancer cells during metastasis
G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …
extensive research, targeting metastatic seeding and colonization is still an unresolved …
Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …
however, some nutrients available at distant organs may inherently promote metastatic …
Lipids as mediators of cancer progression and metastasis
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
controlled by different regulatory mechanisms. In this context, the contribution of cancer …
Amino acid depletion therapies: starving cancer cells to death
M Butler, LT van der Meer, FN van Leeuwen - Trends in Endocrinology & …, 2021 - cell.com
Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …
The emerging role of lactate in tumor microenvironment and its clinical relevance
S Chen, Y Xu, W Zhuo, L Zhang - Cancer Letters, 2024 - Elsevier
In recent years, the significant impact of lactate in the tumor microenvironment has been
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …
Cycling back to folate metabolism in cancer
Metabolic changes contribute to cancer initiation and progression through effects on cancer
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …
Sources and sinks of serine in nutrition, health, and disease
Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …
Spatial metabolomics principles and application to cancer research
Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …