Microarray-based gene expression profiling has had a major effect on our understanding of
breast cancer. Breast cancer is now perceived as a heterogeneous group of different …

Cancer is a group of diseases characterized by the uncontrolled growth and spread of
abnormal cells and oncology is a branch of medicine that deals with tumors. The last decade …

The combination of PD-L1 inhibitor durvalumab and PARP inhibitor olaparib added to
standard paclitaxel neoadjuvant chemotherapy (durvalumab/olaparib/paclitaxel [DOP]) was …

Purpose To determine the long-term prognosis in each phenotypic subset of breast cancer
related to residual cancer burden (RCB) after neoadjuvant chemotherapy alone, or with …

Purpose: The clinical relevancy of the 7-subtype classification of triple-negative breast
cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated the …

Proliferating mammalian cells use glutamine as a source of nitrogen and as a key
anaplerotic source to provide metabolites to the tricarboxylic acid cycle (TCA) for …

Purpose Current immunohistochemical (IHC)-based definitions of luminal A and B breast
cancers are imperfect when compared with multigene expression-based assays. In this …

Context Prediction of high probability of survival from standard cancer treatments is
fundamental for individualized cancer treatment strategies. Objective To develop a predictor …

Molecular classification of cancers into subtypes has resulted in an advance in our
understanding of tumour biology and treatment response across multiple tumour types …

Abstract Background Single sample predictors (SSPs) and Subtype classification models
(SCMs) are gene expression–based classifiers used to identify the four primary molecular …