Inhibitory neurons, although relatively few in number, exert powerful control over brain
circuits. They stabilize network activity in the face of strong feedback excitation and actively …

Nervous systems use excitatory cell assemblies to encode and represent sensory percepts.
Similarly, synaptically connected cell assemblies or “engrams” are thought to represent …

Implantable devices capable of targeted and reversible blocking of peripheral nerve activity
may provide alternatives to opioids for treating pain. Local cooling represents an attractive …

A fundamental impediment to understanding the brain is the availability of inexpensive and
robust methods for targeting and manipulating specific neuronal populations. The need to …

The posterior parietal cortex, along with temporal and prefrontal cortices, is one of the three
major associative regions in the cortex of the mammalian brain. It is situated between the …

Overlearning refers to the continued training of a skill after performance improvement has
plateaued. Whether overlearning is beneficial is a question in our daily lives that has never …

Physical features of sensory stimuli are fixed, but sensory perception is context dependent.
The precise mechanisms that govern contextual modulation remain unknown. Here, we …

Neocortical inhibitory neurons exhibit remarkably diverse morphology, physiological
properties and connectivity. Genetic access to molecularly defined subtypes of inhibitory …

Learning to vocalize depends on the ability to adaptively modify the temporal and spectral
features of vocal elements. Neurons that convey motor-related signals to the auditory system …

Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several
neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human …