Breast cancer (BC) involves complex signaling networks characterized by extensive cross-
communication and feedback loops between and within multiple signaling cascades. Many …

Cell–matrix adhesions are essential for cell migration, tissue organization and
differentiation, therefore playing central roles in embryonic development, remodeling and …

The YAP/TAZ transcriptional programme is not only a well-established driver of cancer
progression and metastasis but also an important stimulator of tissue regeneration. Here we …

Many G protein-coupled receptors activate growth factor receptors, although the
mechanisms controlling this transactivation are unclear. We have identified two proline-rich …

Historically, great efforts have been made to elucidate the biochemical pathways that direct
the complex process of wound healing; however only recently has there been recognition of …

The role of metabolism in tumor growth and chemoresistance has received considerable
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …

The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target
cells in a specific cell cycle phase (eg, antimitotics or DNA synthesis inhibitors/replication …

Glioblastoma multiforme is extraordinarily aggressive due to the propensity of cells to
migrate away from the tumor core into the surrounding normal brain. In this report, we …

Osteoclast activation is important for bone remodeling and is altered in multiple bone
disorders. This process requires cell adhesion and extensive actin cytoskeletal …

Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family and is
highly expressed in brain and hematopoietic cells. Pyk2 plays diverse functions in cells …