Tumor-draining lymph nodes: At the crossroads of metastasis and immunity
Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
Revisiting the mechanisms of CNS immune privilege
Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …
Lymphatic system in cardiovascular medicine
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …
New developments in clinical aspects of lymphatic disease
PS Mortimer, SG Rockson - The Journal of clinical …, 2014 - Am Soc Clin Investig
The lymphatic system is fundamentally important to cardiovascular disease, infection and
immunity, cancer, and probably obesity—the four major challenges in healthcare in the 21st …
immunity, cancer, and probably obesity—the four major challenges in healthcare in the 21st …
The lymphatic system: integral roles in immunity
The lymphatic vasculature is not considered a formal part of the immune system, but it is
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …
The emerging importance of lymphatics in health and disease: an NIH workshop report
The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …
Lymphatic vessels regulate immune microenvironments in human and murine melanoma
Lymphatic remodeling in tumor microenvironments correlates with progression and
metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor …
metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor …
Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance
J Dubrot, FV Duraes, L Potin, F Capotosti… - Journal of Experimental …, 2014 - rupress.org
Dendritic cells (DCs), and more recently lymph node stromal cells (LNSCs), have been
described to tolerize self-reactive CD8+ T cells in LNs. Although LNSCs express MHCII, it is …
described to tolerize self-reactive CD8+ T cells in LNs. Although LNSCs express MHCII, it is …
Emerging roles of lymphatic endothelium in regulating adaptive immunity
Emerging research on the roles of stromal cells in modulating adaptive immune responses
has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the …
has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the …
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
The mechanisms maintaining adult lymphatic vascular specialization throughout life and
their role in coordinating inter-organ communication to sustain homeostasis remain elusive …
their role in coordinating inter-organ communication to sustain homeostasis remain elusive …