Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): Principles and mechanisms

H Ashar, A Ranjan - Pharmacology & Therapeutics, 2023 - Elsevier
High intensity focused ultrasound (HIFU) is a non-invasive and non-ionizing sonic energy-
based therapeutic technology for inducing thermal and non-thermal effects in tissues …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Exploiting the mechanical effects of ultrasound for noninvasive therapy

MA O'Reilly - Science, 2024 - science.org
Focused ultrasound is a platform technology capable of eliciting a wide range of biological
responses with high spatial precision deep within the body. Although focused ultrasound is …

Magic bubbles: utilizing histotripsy to modulate the tumor microenvironment and improve systemic anti-tumor immune responses

KM Imran, A Ganguly, T Paul, M Powar… - International Journal …, 2023 - Taylor & Francis
Focused Ultrasound (FUS) is emerging as a promising primary and adjunct therapy for the
treatment of cancer. This includes histotripsy, which is a noninvasive, non-ionizing, non …

Histotripsy ablation of spontaneously occurring canine bone tumors

LN Ruger, AN Hay, JM Gannon… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with
limited non-surgical treatment options. As the first completely non-invasive and non-thermal …

Ablative and immunostimulatory effects of histotripsy ablation in a murine osteosarcoma model

AN Hay, KM Imran, A Hendricks-Wenger, JM Gannon… - Biomedicines, 2023 - mdpi.com
Background: Osteosarcoma (OS) is the most frequently occurring malignant bone tumor in
humans, primarily affecting children and adolescents. Significant advancements in treatment …

Characterizing the ablative effects of histotripsy for osteosarcoma: in vivo study in dogs

LN Ruger, AN Hay, ER Vickers, SL Coutermarsh-Ott… - Cancers, 2023 - mdpi.com
Simple Summary Histotripsy is a non-invasive focused ultrasound therapy, in development,
for treating osteosarcoma (OS). Small pilot studies describing ex vivo and in vivo histotripsy …

Mechanical high-intensity focused ultrasound (histotripsy) in dogs with spontaneously occurring soft tissue sarcomas

L Ruger, E Yang, J Gannon, H Sheppard… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Introduction: Histotripsy is a non-invasive focused ultrasound therapy that uses controlled
acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports …

[HTML][HTML] Successful in situ targeting of pancreatic tumors in a novel orthotopic porcine model using histotripsy

KM Imran, J Gannon, HA Morrison, JD Tupik… - Ultrasound in medicine …, 2023 - Elsevier
Objective New therapeutic strategies and paradigms are direly needed to treat pancreatic
cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major …

Histotripsy ablation for the treatment of feline injection site sarcomas: a first-in-cat in vivo feasibility study

L Ruger, E Yang, S Coutermarsh-Ott… - International Journal …, 2023 - Taylor & Francis
Purpose Feline soft tissue sarcoma (STS) and injection site sarcoma (fISS) are rapidly
growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a …