Viral evasion of the complement system and its importance for vaccines and therapeutics

J Mellors, T Tipton, S Longet, M Carroll - Frontiers in immunology, 2020 - frontiersin.org
The complement system is a key component of innate immunity which readily responds to
invading microorganisms. Activation of the complement system typically occurs via three …

A contemporary review on pathogenesis and immunity of COVID-19 infection

R Mirzaei, S Karampoor, M Sholeh, P Moradi… - Molecular biology …, 2020 - Springer
Emerging of the COVID-19 pandemic has raised interests in the field of biology and
pathogenesis of coronaviruses; including interactions between host immune reactions …

Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

A Nokkari, H Abou-El-Hassan, Y Mechref… - Progress in …, 2018 - Elsevier
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Microbial evasion of the complement system: A continuous and evolving story

MT Heggi, HT Nour El-Din, DI Morsy… - Frontiers in …, 2024 - frontiersin.org
The complement system is a fundamental part of the innate immune system that plays a key
role in the battle of the human body against invading pathogens. Through its three …

Direct enhancement of viral neutralising antibody potency by the complement system: a largely forgotten phenomenon

J Mellors, M Carroll - Cellular and Molecular Life Sciences, 2024 - Springer
Neutralisation assays are commonly used to assess vaccine-induced and naturally acquired
immune responses; identify correlates of protection; and inform important decisions on the …

Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study

AK Ram, RP Kanojia, A Bhatia, P Menon, RW Minz… - Journal of …, 2023 - Elsevier
To identify and evaluate differentially expressed plasma proteins in biliary atresia (BA), we
performed plasma proteome profiling using liquid chromatography with tandem mass …

Interactions of viruses and the humoral innate immune response

BE Maloney, KD Perera, DRD Saunders… - Clinical …, 2020 - Elsevier
The innate immune response is crucial for defense against virus infections where the
complement system, coagulation cascade and natural antibodies play key roles. These …

Protein degradome of spinal cord injury: Biomarkers and potential therapeutic targets

H Abou-El-Hassan, S Bsat, F Sukhon, EJ Assaf… - Molecular …, 2020 - Springer
Degradomics is a proteomics sub-discipline whose goal is to identify and characterize
protease-substrate repertoires. With the aim of deciphering and characterizing key signature …

[HTML][HTML] Complement-activated fragment Ba functions as an antibacterial protein and mediates immune responses in lower vertebrates

X **, H Zhang, Z Feng, H Liu, X Wang, H Luo… - Journal of Biological …, 2025 - Elsevier
The complement system plays an important role in antibacterial infection and immune
regulation. Ba, an important complement component, is produced and released by the …

[PDF][PDF] Pathophysiological mechanisms of disease severity in COVID-19: An update

MHB Siam, SMDM Abedin, A Ahmed… - J. Adv. Biotechnol …, 2020 - researchgate.net
The pandemic of COVID-19 has created a confounding global health crisis with more than
25 million cases and 870,000 deaths worldwide. The novel coronavirus, SARS-CoV-2 …