[HTML][HTML] What is a cell type and how to define it?
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
phenotypic properties at multiple levels, making them challenging to define, categorize, and …
Astrocyte-neuron metabolic cooperation shapes brain activity
The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …
burden that requires precise coupling between neurotransmission and energy metabolism …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Dysregulation of brain and choroid plexus cell types in severe COVID-19
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms,–. However, an unbiased understanding of the …
COVID-19 can suffer neurological symptoms,–. However, an unbiased understanding of the …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
Hippocampal GABAergic interneurons and memory
One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …
efficiently and durably capture and store information. It must process continuous input from …
[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
[HTML][HTML] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …
or genetic attributes. To better constrain the definition of neuronal cell types, we …
Local connectivity and synaptic dynamics in mouse and human neocortex
We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …
dataset. Through its application, we reveal principles that relate cell type to synaptic …
Circuit organization of the rodent medial prefrontal cortex
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …