The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Chiral phosphoric acids derived from axially chiral biaryls and related chiral Brønsted acids
have emerged as an attractive and widely applicable class of enantioselective …

INTRODUCTION The development of new synthetic methods in organic chemistry is
traditionally accomplished through empirical optimization. Catalyst design, wherein …

Presented is the first enantioselective copper‐catalyzed 1, 6‐conjugate addition of bis
(pinacolato) diboron to para‐quinone methides. The reaction proceeds with excellent yields …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

We disclose herein a highly enantioselective protocol for the Brønsted acid-catalyzed
addition of indoles and phenols to in situ-generated ortho-quinone methides which deliver …

Stereospecific coupling of benzylic carbamates and pivalates with aryl-and
heteroarylboronic esters has been developed. The reaction proceeds with selective …

Synthetic application of asymmetric catalysis relies on strategic alignment of bond
construction to creation of chirality of a target molecule. Remote desymmetrization offers …

Chiral indole derivatives are an intriguing class of heterocyclic compounds; their structural
motifs are frequently found in natural products and synthetic compounds with significant …

The reaction of racemic diarylmethylamines,(Ar1Ar2CHNR2), where Ar1 is substituted with a
2-hydroxy group, with arylboroxines (Ar3BO) 3 in the presence of a chiral diene-rhodium …