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Systemic sclerosis
ER Volkmann, K Andréasson, V Smith - The Lancet, 2023 - thelancet.com
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune
connective-tissue disease. Once considered an untreatable and unpredictable condition …
connective-tissue disease. Once considered an untreatable and unpredictable condition …
Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis
The modified Rodnan skin score (mRSS) is a measure of skin thickness and is used as a
primary or secondary outcome measure in clinical trials of systemic sclerosis (scleroderma) …
primary or secondary outcome measure in clinical trials of systemic sclerosis (scleroderma) …
Nintedanib for systemic sclerosis–associated interstitial lung disease
Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
Myeloablative autologous stem-cell transplantation for severe scleroderma
Background Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma)
often has a devastating outcome. We compared myeloablative CD34+ selected autologous …
often has a devastating outcome. We compared myeloablative CD34+ selected autologous …
Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group …
DP Tashkin, MD Roth, PJ Clements… - The Lancet …, 2016 - thelancet.com
Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However …
of scleroderma-related interstitial lung disease when compared with placebo. However …
Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the …
Summary Background In the Safety and Efficacy of Nintedanib in Systemic Sclerosis
(SENSCIS) trial, nintedanib reduced the rate of decline in forced vital capacity (FVC) in …
(SENSCIS) trial, nintedanib reduced the rate of decline in forced vital capacity (FVC) in …
How we treat chronic graft-versus-host disease
MED Flowers, PJ Martin - Blood, The Journal of the American …, 2015 - ashpublications.org
Chronic graft-versus-host disease (GVHD) remains a common and potentially life-
threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2 …
threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2 …
Cutaneous manifestations of scleroderma and scleroderma-like disorders: a comprehensive review
Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …
Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an …
Background Non-randomised studies of haemopoietic stem-cell transplantation (HSCT) in
systemic sclerosis have shown improvements in lung function and skin flexibility but high …
systemic sclerosis have shown improvements in lung function and skin flexibility but high …
Association of the autoimmune disease scleroderma with an immunologic response to cancer
CG Joseph, E Darrah, AA Shah, AD Skora… - Science, 2014 - science.org
Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-
react with endogenous molecules. Scleroderma is an autoimmune connective tissue …
react with endogenous molecules. Scleroderma is an autoimmune connective tissue …