[HTML][HTML] Multidrug-resistant Pseudomonas aeruginosa triggers differential inflammatory response in patients with endophthalmitis

P Naik, S Singh, D Rudraprasad… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: Infections with multidrug-resistant Pseudomonas aeruginosa (MDR-PA) lead to
poor clinical outcomes in endophthalmitis patients, and its interactions with the host immune …

[HTML][HTML] Transcriptomic and histological analysis of exacerbated immune response in multidrug-resistant Pseudomonas aeruginosa in a murine model of …

P Naik, S Pandey, MN Naik, DK Mishra… - Frontiers in …, 2022 - frontiersin.org
Multidrug-resistant (MDR) endophthalmitis is a serious threat to the whole spectrum of
therapeutic procedures associated with the risk of managing and preventing vision loss. We …

Distinct Effects of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Cell Wall Component-Induced Inflammation on the Iron Metabolism of …

E Pandur, K Tamási, R Pap, G Jánosa… - International Journal of …, 2021 - mdpi.com
Macrophages are essential immune cells of the innate immune system. They participate in
the development and regulation of inflammation. Macrophages play a fundamental role in …

Multi‐Functional Small Molecules with Temporal Charge‐Switchability Tackle Infection and Inflammation

S Barman, G Dhanda, P Naik… - Advanced …, 2022 - Wiley Online Library
The alarming situation in public healthcare caused by ever‐increasing catastrophe of
antimicrobial resistance, recurrent infections, and associated inflammation has accelerated …

Differential inflammatory response to Aspergillus flavus and Candida albicans infection in human retinal pigment epithelial cells: Role in treatment of endophthalmitis

J Gandhi, J Joseph - Journal of Medical Mycology, 2021 - Elsevier
Objective Fungal endophthalmitis is an emerging vision-threatening complication in tropical
countries and the Retinal pigment epithelial cells (RPE) are said to play a major role in the …

Proteomic landscape of extracellular vesicles in human retinal cells infected with Staphylococcus aureus and Pseudomonas aeruginosa: Role in endophthalmitis

D Rudraprasad, J Joseph - Experimental Cell Research, 2023 - Elsevier
Abstract Extracellular Vesicles (EVs) have evolved as a promising entity for develo**
diagnostic and therapeutic biomarkers. We profiled global EV proteome of EVs from Human …

Mechanism of Qiguiyin Decoction Sensitizing Levofloxacin Against Multidrug-Resistant Pseudomonas aeruginosa Infection Based on PK-PD and Antibody Chip …

Y Li, L Ji, T Liu, G Xu, K Wang, L Mu… - Infection and Drug …, 2024 - Taylor & Francis
Background Qiguiyin decoction (QGYD) is a traditional Chinese medicine (TCM) and its
combined application with levofloxacin (LVFX) has been confirmed effective in the clinical …

Temporal Transcriptome Analysis Suggests Modulation of Key Pathways and Hub Genes in a Mice Model of Multi-Drug Resistant (MDR) Pseudomonas aeruginosa …

P Naik, J Joseph - Current Eye Research, 2022 - Taylor & Francis
Purpose Increasing incidence of multidrug-resistant Pseudomonas aeruginosa (MDR-PA)
causing endophthalmitis challenges our ability to manage this vision-threatening condition …

Difference in Host Immune response to Methicillin-Resistant and Methicillin Sensitive Staphylococcus aureus (MRSA and MSSA) Endophthalmitis

P Naik, J Joseph - Ocular Immunology and Inflammation, 2022 - Taylor & Francis
Purpose The study aimed to understand the differential immune response of methicillin
susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) …

Antimicrobial Resistance in the Diseased Human Eye: Endophthalmitis

J Joseph - Antimicrobial Resistance of the Human Eye - taylorfrancis.com
Most studies of drug resistance emergence during antibiotic treatment focus almost
exclusively on the dynamics of bacteria and the drug and neglect the contribution of immune …