Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

In response to skeletal muscle contraction during exercise, paracrine factors coordinate
tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing …

Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Aim To study the effects of exercise on lysosomal functions. Methods Mouse exercise model
was established and wheel running was scheduled as 18 rpm (14: 00‐17: 00), 5 d/wk, for 8 …

Zinc is an essential element for all forms of life, and one in every ten human proteins is a
zinc protein. Zinc has catalytic, structural and signalling functions and its correct …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an
evolutionarily conserved degradation pathway, which is a highly conserved cellular …

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and
pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely …

Pre-clinical evidence shows that neuropathy is associated with complex neuroimmune
responses, which in turn are associated with increased intensity and persistence of …