Cholangiocarcinoma—novel biological insights and therapeutic strategies

SI Ilyas, S Affo, L Goyal, A Lamarca… - Nature Reviews …, 2023 - nature.com
In the past 5 years, important advances have been made in the scientific understanding and
clinical management of cholangiocarcinoma (CCA). The cellular immune landscape of CCA …

[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer

DY Oh, A Ruth He, S Qin, LT Chen, T Okusaka… - NEJM …, 2022 - evidence.nejm.org
Durvalumab Combination for Biliary Tract Cancer This trial randomly assigned patients with
previously untreated locally advanced or metastatic biliary tract cancer to receive …

[HTML][HTML] Clinical treatment of cholangiocarcinoma: an updated comprehensive review

A Elvevi, A Laffusa, M Scaravaglio, RE Rossi… - Annals of …, 2022 - Elsevier
Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms of the bile ducts and
represents the second most common hepatic cancer after hepatocellular carcinoma; it is sub …

Map** the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression

A Guillot, M Winkler, MS Afonso, A Aggarwal… - Hepatology, 2023 - journals.lww.com
Conclusions: Loss of hepatocytes and increased ductular reaction are tightly associated with
monocyte-derived macrophage accumulation and represent the most prominent common …

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y **ng… - Signal transduction and …, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

[HTML][HTML] Artificial intelligence in liver cancers: Decoding the impact of machine learning models in clinical diagnosis of primary liver cancers and liver cancer …

A Bakrania, N Joshi, X Zhao, G Zheng, M Bhat - Pharmacological research, 2023 - Elsevier
Liver cancers are the fourth leading cause of cancer-related mortality worldwide. In the past
decade, breakthroughs in the field of artificial intelligence (AI) have inspired development of …

Artificial intelligence in endoscopic imaging for detection of malignant biliary strictures and cholangiocarcinoma: A systematic review

B Njei, TR McCarty, BP Mohan, L Fozo… - Annals of …, 2023 - pmc.ncbi.nlm.nih.gov
Background Artificial intelligence (AI), when applied to computer vision using a
convolutional neural network (CNN), is a promising tool in “difficult-to-diagnose” conditions …

JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis

S Lei, W Cao, Z Zeng, Z Zhang, B **, Q Tian… - Cell death & …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) are a novel class of noncoding RNAs that have emerged
as critical regulators and biomarkers in various cancers. Nevertheless, the expression profile …

Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic …

JC Lu, LL Wu, YN Sun, XY Huang, C Gao… - Nature …, 2024 - nature.com
Intratumoral immune status influences tumor therapeutic response, but it remains largely
unclear how the status determines therapies for patients with intrahepatic …