[HTML][HTML] A review of broadly protective monoclonal antibodies to treat Ebola virus disease
P Rijal, FR Donnellan - Current Opinion in Virology, 2023 - Elsevier
Highlights•mAbs mixture targeting independent epitopes are better therapeutics.•Optimizing
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep
AD Rghei, LP van Lieshout, W Cao, S He, K Tierney… - Gene Therapy, 2022 - nature.com
Vectored monoclonal antibody (mAb) expression mediated by adeno-associated virus (AAV)
gene delivery leads to sustained therapeutic mAb expression and protection against a wide …
gene delivery leads to sustained therapeutic mAb expression and protection against a wide …
Taï Forest virus does not cause lethal disease in ferrets
Z Schiffman, F Yan, S He, K Tierney, W Zhu, K Emeterio… - Microorganisms, 2021 - mdpi.com
Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing
severe disease in humans and nonhuman primates, often with high case fatality rates …
severe disease in humans and nonhuman primates, often with high case fatality rates …
Elucidating the cellular and molecular mechanisms that govern filovirus pathogenesis within ferrets with emphasis on Marburg virus
Z Schiffman - 2024 - mspace.lib.umanitoba.ca
Recently, the ferret has gained attention as a novel animal model for studying filoviruses.
Ferrets are highly susceptible to several orthoebolaviruses, including Ebola virus (EBOV) …
Ferrets are highly susceptible to several orthoebolaviruses, including Ebola virus (EBOV) …