Nanoparticles are highly efficient additives for modification of cement products, even at small
concentrations (≤ 1%). The main modifications are (typical ranges shown, though great …

The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural
proteins, signaling molecules, and proteases. Changes in the overall integrity and …

In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after
injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the …

Background—Several microRNAs (miRs) have been shown to regulate gene expression in
the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 …

Adverse cardiac remodelling is a major cause of morbidity and mortality following acute
myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and …

Cardiovascular disease is a major chronic complication of obesity and diabetes. Due to
several patients with obesity and diabetes, it is necessary to urgently explore early …

MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression
predominantly at the post-transcriptional level. Far from being simple intracellular regulators …

miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene
expression. miRNAs are expressed in the heart where they regulate multiple …

Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects
are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA …

Cardiac hypertrophy is a primary predictor of progressive heart disease that often results in
heart failure. Growing evidence has demonstrated that microRNAs (miRNAs) play a critical …