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The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
The open field is a very popular animal model of anxiety-like behavior. An overview of the
literature on the action elicited by effective or putative anxiolytics in animal subjected to this …
literature on the action elicited by effective or putative anxiolytics in animal subjected to this …
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …
Neurosteroids: endogenous role in the human brain and therapeutic potentials
This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …
Nongenomic actions of steroid hormones
R Lösel, M Wehling - Nature reviews Molecular cell biology, 2003 - nature.com
Steroid hormones modulate many physiological processes. The effects of steroids that are
mediated by the modulation of gene expression are known to occur with a time lag of hours …
mediated by the modulation of gene expression are known to occur with a time lag of hours …
Multiple actions of steroid hormones—a focus on rapid, nongenomic effects
According to the traditional model, steroid hormones bind to intracellular receptors and
subsequently modulate transcription and protein synthesis, thus triggering genomic events …
subsequently modulate transcription and protein synthesis, thus triggering genomic events …
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
Nongenomic steroid action: controversies, questions, and answers
RM Losel, E Falkenstein, M Feuring… - Physiological …, 2003 - journals.physiology.org
Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …
Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: A landmark journey from concept to clinic in neurosteroid …
This article describes the critical role of neurosteroids in postpartum depression (PPD) and
outlines the landmark pharmacological journey of brexanolone as a first-in-class …
outlines the landmark pharmacological journey of brexanolone as a first-in-class …
Sigma receptors [σ Rs]: biology in normal and diseased states
CG Rousseaux, SF Greene - Journal of Receptors and Signal …, 2016 - Taylor & Francis
This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance
P Zheng - Progress in neurobiology, 2009 - Elsevier
Neuroactive steroids refer to steroids that are capable of regulating neuronal activities.
Neuroactive steroids, synthesized either de novo in the nervous tissue or in the peripheral …
Neuroactive steroids, synthesized either de novo in the nervous tissue or in the peripheral …