Background Since the introduction of what became today's standard for cryo-embedding of
biological macromolecules at native conditions more than 30 years ago, techniques and …

Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their
environment with transmembrane chemoreceptor proteins. These receptors operate in …

Highlights•Cryo-ET and subtomogram averaging allow visualizing macromolecular
complexes in close to physiological conditions.•This offers a significant potential for in situ …

Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins
to mediate the signal transduction that ultimately controls cell motility. A mechanistic …

Electron cryotomography (ECT) enables intact cells to be visualized in 3D in an essentially
native state to'macromolecular'(∼ 4 nm) resolution, revealing the basic architectures of …

Bacteria sense and respond to their environment through a highly conserved assembly of
transmembrane chemoreceptors (MCPs), the histidine kinase CheA, and the coupling …

The Escherichia coli chemosensory system consists of large arrays of transmembrane
chemoreceptors associated with a dedicated histidine kinase, CheA, and a linker protein …

Most motile bacteria sense and respond to their environment through a transmembrane
chemoreceptor array whose structure and function have been well-studied, but many …

Motile bacteria sense chemical gradients with transmembrane receptors organised in
supramolecular signalling arrays. Understanding stimulus detection and transmission at the …

Bacterial chemoreceptors cluster in highly ordered, cooperative, extended arrays with a
conserved architecture, but the principles that govern array assembly remain unclear. Here …