After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of
PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential …

The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

Epilepsy has remained a significant social concern and financial burden globally. Current
therapeutic strategies are based primarily on neurocentric mechanisms that have not proven …

Understanding molecular mechanisms mediating epileptogenesis is critical for develo**
more effective therapies for epilepsy. We recently found that the mammalian target of …

Summary As in Clark and Prout's classic work, we identify three phases of generalised
convulsive status epilepticus, which we call impending, established, and subtle. We review …

Technological advances have paved the way for accelerated genomic discovery and are
bringing precision medicine clearly into view. Epilepsy research in particular is well suited to …

In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …