NRF2 in cardiovascular diseases: a ray of hope!

R Vashi, BM Patel - Journal of cardiovascular translational research, 2021 - Springer
Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is
expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function …

Management of opioid-induced constipation and bowel dysfunction: expert opinion of an Italian multidisciplinary panel

R De Giorgio, FM Zucco, G Chiarioni, S Mercadante… - Advances in …, 2021 - Springer
The prescribing and use of opioid analgesics is increasing in Italy owing to a profusion in the
number and types of opioid analgesic products available, and the increasing prevalence of …

Genetic liability for prescription opioid use and risk of cardiovascular diseases: a multivariable Mendelian randomization study

J Cai, L He, H Wang, X Rong, M Chen, Q Shen, X Li… - …, 2022 - Wiley Online Library
Background and aims Observational studies have yielded conflicting results on the
association of prescription opioid use (POU) with the risk of cardiovascular diseases (CVD) …

De novo variants in exomes of congenital heart disease patients identify risk genes and pathways

C Sevim Bayrak, P Zhang, M Tristani-Firouzi, BD Gelb… - Genome medicine, 2020 - Springer
Background Congenital heart disease (CHD) affects~ 1% of live births and is the most
common birth defect. Although the genetic contribution to the CHD has been long …

Population data study reveals pain as a possible protective factor against cerebrovascular disease in cancer patients

Y Wei, D Lin, Y Lian, Q Wei, L Zheng, K Yuan… - Scientific Reports, 2024 - nature.com
The purpose of this study is to investigate the relationship between chronic pain and the
mortality rate of cerebrovascular disease (CVD) in cancer patients. Thus, we performed a …

Prenatal morphine exposure increases cardiovascular disease risk and programs neurogenic hypertension in the adult offspring

N Ahmed, A Kassis, J Malone, J Yang, E Zamzami… - …, 2023 - Am Heart Assoc
Background: The opioid overdose and opioid use disorder epidemics are concomitant with
increased metabolic and CVD risk. Although opioid use disorder causes adverse pregnancy …

Prescribed opioid use is associated with adverse cardiovascular outcomes in community‐dwelling older persons

SM Liew, EK Chowdhury, ME Ernst… - ESC heart …, 2022 - Wiley Online Library
Aims Prescribed opioids are commonly used in the older community‐dwelling population for
the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are …

Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial

G Hao, J Wu, S Yu, K Liu, Y Xue, Q Gong, R **e… - Journal of Intensive …, 2024 - Springer
Background The optimal sedative regime for noninvasive ventilation (NIV) intolerance
remains uncertain. The present study aimed to assess the efficacy and safety of remifentanil …

Exploring unconventional risk-factors for cardiovascular diseases: has opioid therapy been overlooked?

O Ogungbe, L Akil, HA Ahmad - International journal of environmental …, 2019 - mdpi.com
Approximately 2150 adults die every day in the US from Cardiovascular Diseases (CVD)
and another 115 deaths are attributed to opioid-related causes. Studies have found …

Implication of Opioid Receptors in the Antihypertensive Effect of a Bovine Casein Hydrolysate and αs1-Casein-Derived Peptides

L Sánchez-Rivera, P Ferreira Santos… - Journal of agricultural …, 2019 - ACS Publications
The antihypertensive activity of two αs1-casein-derived peptides and casein hydrolysate
containing these sequences was evaluated in the presence of naloxone. The activity was …