Genetic determinants of HIV‐1 infection and progression to AIDS: Immune response genes

G Kaur, N Mehra - Tissue antigens, 2009 - Wiley Online Library
Genomic studies involving well‐defined multicenter cohorts of HIV‐1/AIDS covering multiple
populations have led to a greater understanding of the role of host determinants in viral …

Functional gene polymorphisms in canadian aboriginal populations with high rates of tuberculosis

L Larcombe, PH Orr, AM Lodge… - Journal of Infectious …, 2008 - academic.oup.com
The present study determined whether a pattern of functional single-nucleotide
polymorphisms (SNPs) was present that could predispose a Dené cohort to a suboptimal …

Genetic correlates influencing immunopathogenesis of HIV infection

G Sharma, G Kaur, N Mehra - Indian Journal of Medical Research, 2011 - journals.lww.com
Variability to HIV infection, its progression as well as responsiveness to antiretroviral therapy
(ART) is observed among individuals including viraemia controllers or exposed uninfected …

Effect of IL-12B, IL-2, TGF-β1, and IL-4 Polymorphism and Expression on Hepatitis B Progression

R Saxena, YK Chawla, I Verma… - Journal of Interferon & …, 2014 - liebertpub.com
The hepatitis B virus (HBV) infection-induced chronic inflammation is considered to be the
major etiological factor for HBV-related disease chronicity. Cytokines act as the key …

Polymorphisms in the IFNγ, IL‐10, and TGFβ Genes May Be Associated with HIV‐1 Infection

F Bonfim Freitas, S Souza Lima, RNM Feitosa… - Disease …, 2015 - Wiley Online Library
Objective. This study investigated possible associations between the TNFα‐308G/A, IFN+
874A/T, IL‐6‐174C/G, IL‐10‐1082A/G, and TGFβ‐509C/T polymorphisms with HIV‐1 …

TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil

JEL Visentainer, AM Sell, GC Da Silva… - International journal …, 2008 - Wiley Online Library
This study attempted to establish single nucleotide polymorphism frequencies of TNF, IL6,
IFNG, IL10 and TGFB1 genes among healthy individuals from South and Southeast Brazil …

IFN-γ (+874) and not TNF-α (−308) is associated with HBV-HCC risk in India

R Saxena, YK Chawla, I Verma, J Kaur - Molecular and cellular …, 2014 - Springer
Tumor necrosis factor (TNF)-α and interferon (IFN)-γ, the pro-inflammatory Th1 cytokines are
the indispensable coordinators of the inflammatory responses involved in hepatitis B virus …

Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients

DL Gupta, PK Nagar, VK Kamal, S Bhoi… - Scandinavian journal of …, 2015 - Springer
Introduction The susceptibility to adverse outcome from critical injury (occurrence of sepsis,
septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different …

IL-6–174 G/C and ApoE gene polymorphisms in Alzheimer's and vascular dementia patients attending the cognitive disorder clinic of the all India Institute of Medical …

N Mansoori, M Tripathi, R Alam, K Luthra… - Dementia and geriatric …, 2011 - karger.com
Background: Remarkable improvement in the life expectancy of the Indian population is
expected to commensurate with the increase in number of dementia cases. Among various …

Association of interleukin-6 (− 174G> C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: an exploratory study

R Upadhyay, M Jain, S Kumar, UC Ghoshal, B Mittal - Clinical Immunology, 2008 - Elsevier
Chronic inflammation plays a role in transformation from normal cell to malignant state.
Interleukin-6 (IL-6) regulates inflammation and various physiological processes. IL-6 …