Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

J Ren, Y Bi, JR Sowers, C Hetz, Y Zhang - Nature Reviews Cardiology, 2021 - nature.com
Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review

CI Chukwuma, MG Matsabisa, MA Ibrahim… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Diabetes and hypertension are pathophysiologically
related diseases that co-exist with a wider complex of metabolic diseases having similar set …

CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis

L Chen, Z Yin, X Qin, X Zhu, X Chen, G Ding… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2D) contributes to sustained inflammation and myopathic
changes in the heart although the precise interplay between the two remains largely …

Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome

S Devalaraja, S Jain, H Yadav - Food research international, 2011 - Elsevier
The prevalence and severity of obesity, type 2-diabetes, and the resultant metabolic
syndrome are rapidly increasing. As successful preventive and therapeutic strategies for …

Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics

M Abudureyimu, X Luo, X Wang… - Journal of Molecular …, 2022 - academic.oup.com
Type 2 diabetes mellitus (T2DM or T2D) is a devastating metabolic abnormality featured by
insulin resistance, hyperglycemia, and hyperlipidemia. T2D provokes unique metabolic …

Treating type 2 diabetes mellitus with traditional Chinese and Indian medicinal herbs

Z Wang, J Wang, P Chan - Evidence‐Based Complementary …, 2013 - Wiley Online Library
Type II diabetes mellitus (T2DM) is a fast‐growing epidemic affecting people globally.
Furthermore, multiple complications and comorbidities are associated with T2DM. Lifestyle …

A review of Chinese herbal medicine for the treatment of chronic heart failure

Y Wang, Q Wang, C Li, L Lu, Q Zhang… - Current …, 2017 - ingentaconnect.com
Heart failure is one of the major causes of mortality worldwide and it is the end stage of
several cardiovascular diseases. Traditional Chinese medicine has been used in the …

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms

M Guo, Y Liu, D Shi - BioMed Research International, 2016 - Wiley Online Library
Tetramethylpyrazine (TMP), a pharmacologically active component isolated from the
rhizome of the Chinese herb Rhizoma Chuanxiong (Chuanxiong), has been clinically used …

The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis

K He, S Song, Z Zou, M Feng, D Wang… - Phytotherapy …, 2016 - Wiley Online Library
Hypoglycemic activity‐guided separation of ethanol extracts from the fruits of Cornus
officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid …