Molecular basis of human sperm capacitation

LC Puga Molina, GM Luque, PA Balestrini… - Frontiers in cell and …, 2018 - frontiersin.org
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Ca2+ signaling in mammalian spermatozoa

M Finkelstein, N Etkovitz, H Breitbart - Molecular and Cellular …, 2020 - Elsevier
Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …

Redox regulation and oxidative stress: The particular case of the stallion spermatozoa

FJ Peña, C O'Flaherty, JM Ortiz Rodríguez… - Antioxidants, 2019 - mdpi.com
Redox regulation and oxidative stress have become areas of major interest in spermatology.
Alteration of redox homeostasis is recognized as a significant cause of male factor infertility …

Progesterone, spermatozoa and reproduction: An updated review

L Tamburrino, S Marchiani, M Muratori, M Luconi… - Molecular and cellular …, 2020 - Elsevier
The rapid effects of steroids on spermatozoa have been demonstrated for the first time more
than three decades ago. Progesterone (P), which is present throughout the female genital …

Discrete dynamic model of the mammalian sperm acrosome reaction: the influence of acrosomal pH and physiological heterogeneity

A Aldana, J Carneiro, G Martínez-Mekler… - Frontiers in …, 2021 - frontiersin.org
The acrosome reaction (AR) is an exocytotic process essential for mammalian fertilization. It
involves diverse physiological changes (biochemical, biophysical, and morphological) that …

Capacitation increases glucose consumption in murine sperm

DM Hidalgo, A Romarowski, MG Gervasi… - Molecular …, 2020 - Wiley Online Library
Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process
known as capacitation. During capacitation, sperm change their motility pattern (ie …

[HTML][HTML] What is the importance of sperm subpopulations?

F Martínez-Pastor - Animal Reproduction Science, 2022 - Elsevier
The study of sperm subpopulations spans three decades. The origin, meaning, and practical
significance, however, are less clear. Current technology for assessing sperm morphology …

Boar semen improvement through sperm capacitation management, with emphasis on zinc ion homeostasis

P Sutovsky, K Kerns, M Zigo, D Zuidema - Theriogenology, 2019 - Elsevier
Critical to fertilization success, sperm capacitation within the female oviductal sperm
reservoir endows mammalian spermatozoa with hyperactivated motility and capacity to …

Human sperm phosphoproteome reveals differential phosphoprotein signatures that regulate human sperm motility

D Martin-Hidalgo, R Serrano, C Zaragoza… - Journal of …, 2020 - Elsevier
Human sperm motility is essential for fertilization and among pathologies underlying male
infertility is asthenozoospermia. Nevertheless, mechanisms regulating sperm motility are not …

Conserved mechanism of bicarbonate-induced sensitization of CatSper channels in human and mouse sperm

JJ Ferreira, P Lybaert, LC Puga-Molina… - Frontiers in Cell and …, 2021 - frontiersin.org
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract.
A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated …