Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the
rise, and Mycobacterium tuberculosis infection is often associated with human …

Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Bacteria that cause disease rely on their ability to counteract and overcome host defenses.
Here, we present a genome-scale study of Mycobacterium tuberculosis (Mtb) that uncovers …

Human tuberculosis is a complex disease caused by bacterial populations that are located
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …

Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

With the advent of HIV and the widespread emergence of drug-resistant strains of
Mycobacterium tuberculosis, newer control strategies in the form of a better vaccine could …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments. A …

Significance: Proline metabolism has complex roles in a variety of biological processes,
including cell signaling, stress protection, and energy production. Proline also contributes to …