Cellular host factors for SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …
and caused a global economic crisis. No effective antiviral drugs are currently available to …
Large-scale integration of the plasma proteome with genetics and disease
The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
describe genome-wide association studies (GWASs) of plasma protein levels measured with …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
Map** the proteo-genomic convergence of human diseases
INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19)
susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) …
susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) …
Uncovering the depths of the human proteome: antibody-based technologies for ultrasensitive multiplexed protein detection and quantification
Probing the human proteome in tissues and biofluids such as plasma is attractive for
biomarker and drug target discovery. Recent breakthroughs in multiplex, antibody-based …
biomarker and drug target discovery. Recent breakthroughs in multiplex, antibody-based …
Synergistic insights into human health from aptamer-and antibody-based proteomic profiling
Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
A genome-wide association study of serum proteins reveals shared loci with common diseases
With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …
become increasingly more complex, yet the functional consequences of most disease …
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
Improved understanding of genetic regulation of the proteome can facilitate identification of
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
Causal associations between cardiorespiratory fitness and type 2 diabetes
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However,
the causality of this relationship and the biological mechanisms that underlie it are unclear …
the causality of this relationship and the biological mechanisms that underlie it are unclear …