[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Distinct changes in endosomal composition promote NLRP3 inflammasome activation
Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin
domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad …
domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad …
Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies
J Sinsky, K Pichlerova, J Hanes - International journal of molecular …, 2021 - mdpi.com
Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …
microtubules, which are important for the normal function of neurons and the brain. In …
The N‐end rule pathway and regulation by proteolysis
A Varshavsky - Protein science, 2011 - Wiley Online Library
The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
NAC guides a ribosomal multienzyme complex for nascent protein processing
Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
The small G proteins of the Arf family and their regulators
AK Gillingham, S Munro - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …
pathways. The majority of such small G proteins are members of the Rab family, which are …
[HTML][HTML] Protein post-translational modifications: In silico prediction tools and molecular modeling
M Audagnotto, M Dal Peraro - Computational and structural biotechnology …, 2017 - Elsevier
Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …
role in numerous biological processes by significantly affecting proteins' structure and …