One of the challenges raised by next generation sequencing (NGS) is the identification of
clinically relevant mutations among all the genetic variation found in an individual. Network …

Adaptive evolution is shaped by the interaction of population genetics, natural selection and
underlying network and biochemical constraints. Variation created by mutation, the raw …

Robustness is a prominent feature of most biological systems. Most previous related studies
have been focused on homogeneous molecular networks. Here we propose a …

Advances in genome-scale molecular biology and molecular genetics have greatly elevated
our knowledge on the basic components of human biology and diseases. At the same time …

В обзоре рассмотрена динамика представлений о феномене сочетания болезней
(коморбидности) у человека. Представлен анализ генетических основ трех форм …

Do genes presenting variation that has been linked to human disease have different
biological properties than genes that have never been related to disease? What is the …

Assessing the causal tissues of human traits and diseases is important for better interpreting
trait-associated genetic variants, understanding disease etiology, and improving treatment …

In this review, the development of ideas focused on the phenomenon of disease
combination (comorbidity) in humans is discussed. The genetic bases of the three forms of …

Human Population Genetics and Genomics provides researchers/students with knowledge
on population genetics and relevant statistical approaches to help them become more …

The genetic basis of phenotypic emergence provides valuable information for assessing
individual risk. While association studies have been pivotal in identifying genetic risk factors …