Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain
(RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in …

Protein–protein association is fundamental to many life processes. However, a microscopic
model describing the structures and kinetics during association and dissociation is lacking …

Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the
random coil. The five following examples suggest that native protein structure can …

Microfluidic systems have shown unequivocal performance improvements over conventional
bench-top assays across a range of performance metrics. For example, specific advances …

The docking field has come of age. The time is ripe to present the principles of docking,
reviewing the current state of the field. Two reasons are largely responsible for the maturity …

Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …

The use of monoclonal antibodies as therapeutics requires optimizing several of their key
attributes. These include binding affinity and specificity, folding stability, solubility …

Understanding the function of biological macromolecules and their complexes at the
physicochemical level requires knowledge of both their structure and dynamics …