[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023‏ - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

[HTML][HTML] Feasibility study of microburst VNS therapy in drug-resistant focal and generalized epilepsy

C Drees, P Afra, R Verner, L Kaye, A Keith, M Jiang… - Brain Stimulation, 2024‏ - Elsevier
Background Vagus nerve stimulation (VNS) at low frequencies (≤ 30 Hz) has been an
established treatment for drug-resistant epilepsy (DRE) for over 25 years. Objective To …

Characterization of Vagus Nerve Stimulation (VNS) Dose-Dependent Effects on EEG Power Spectrum and Synchronization

E Germany Morrison, V Danthine, R Santalucia… - Biomedicines, 2024‏ - mdpi.com
This study investigates the dose-dependent EEG effects of Vagus Nerve Stimulation (VNS)
in patients with drug-resistant epilepsy. This research examines how varying VNS intensities …

Optimized microburst VNS elicits fMRI responses beyond thalamic‐specific response from standard VNS

JP Szaflarski, JB Allendorfer, J Begnaud… - Annals of Clinical …, 2024‏ - Wiley Online Library
Objective In parallel to standard vagus nerve stimulation (VNS), microburst stimulation
delivery has been developed. We evaluated the fMRI‐related signal changes associated …

CM‐Pf deep brain stimulation in polyneuromodulation for epilepsy

WO Tatum, B Freund, EH Middlebrooks… - Epileptic …, 2024‏ - Wiley Online Library
Objective Neuromodulation is a viable option for patients with drug‐resistant epilepsies. We
reviewed the management of patients with two deep brain neurostimulators. In addition …

Compatibility of Standard Vagus Nerve Stimulation and Investigational Microburst Vagus Nerve Stimulation Therapy with fMRI

EH Middlebrooks, JP Szaflarski, J Begnaud… - American Journal of …, 2024‏ - ajnr.org
Vagus nerve stimulation devices are conditionally approved for MR imaging with stimulation
turned off, and the requirement to modify the stimulation settings may be a barrier to …

Changes in myelinated nerve fibers induced by pulsed electrical stimulation: A microstructural perspective on the causes of electrical stimulation side effects

H Zhao, Y Li, Y Zhang, C Zhang - Biochemical and Biophysical Research …, 2024‏ - Elsevier
Electrical brain stimulation technology is widely used in the clinic to treat brain neurological
disorders. However, during treatment, patients may experience side effects such as pain …

Temporal Parameters Determine the Efficacy of Vagus Nerve Stimulation Directed Neural Plasticity

JJA Addo, CL Neifert, T Danaphongse, S Abe, V Ezhil… - bioRxiv, 2024‏ - biorxiv.org
Combining vagus nerve stimulation (VNS) with rehabilitation represents an emerging
treatment for a range of neurological disorders, and identifying stimulation parameters that …

[PDF][PDF] Functional and structural biomarkers to optimize vagus nerve stimulation therapy in drug-resistant epilepsy

A Berger - 2024‏ - dial.uclouvain.be
This doctoral thesis included an industrial part realized in collaboration with Synergia
Medical. Synergia Medical is a start-up founded in 2014 that is develo** optoelectronic …