Single-particle cryogenic electron microscopy (cryo-EM) has emerged as a powerful
technique to visualize the structural landscape sampled by a protein complex. However …

Single-particle cryo-electron microscopy (cryo-EM) is a technique that takes projection
images of biomolecules frozen at cryogenic temperatures. A major advantage of this …

Advances in cryo-electron tomography (cryo-ET) have produced new opportunities to
visualize the structures of dynamic macromolecules in native cellular environments. While …

Macromolecules change their shape (conformation) in the process of carrying out their
functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of …

This article presents an original approach for extracting atomic-resolution landscapes of
continuous conformational variability of biomolecular complexes from cryo electron …

Physics-informed generative modeling for inverse problems in computational imaging is a
fast-growing field encompassing a variety of methods and applications. Here, we review a …