Mechanisms underlying T cell ageing
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
Age-associated remodeling of T cell immunity and metabolism
Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation
Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18
induces their differentiation into memory-like (ML) NK cells; however, the underlying …
induces their differentiation into memory-like (ML) NK cells; however, the underlying …
Significance of bystander T cell activation in microbial infection
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …
infecting pathogens can be activated by cytokines without cognate antigens, termed …
CD8+ Regulatory T Cell – A Mystery to Be Revealed
Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity
Virtual memory T (TVM) cells are a T cell subtype with a memory phenotype but no prior
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …
exposure to foreign antigen. Although TVM cells have antiviral and antibacterial functions …
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
GJW Van Der Windt, D O'Sullivan… - Proceedings of the …, 2013 - National Acad Sciences
A characteristic of memory T (TM) cells is their ability to mount faster and stronger responses
to reinfection than naïve T (TN) cells do in response to an initial infection. However, the …
to reinfection than naïve T (TN) cells do in response to an initial infection. However, the …
Naive T cell maintenance and function in human aging
In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …
The gene regulatory basis of bystander activation in CD8+ T cells
CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …
recognize specific foreign antigens and mount memory responses. However, recent studies …
Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of
pathogens, and TCR repertoire size is believed to decline with age. However, the precise …
pathogens, and TCR repertoire size is believed to decline with age. However, the precise …