Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the
Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic …

Metabolic syndrome is a growing cause of morbidity and mortality worldwide. Metabolic
syndrome is characterized by the presence of a variety of metabolic disturbances including …

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

Rodent models have been invaluable for biomedical research. Preclinical investigations
with rodents allow researchers to investigate diseases by using study designs that are not …

Chronic disease risk is inextricably linked to our early-life environment, where maternal,
fetal, and childhood factors predict disease risk later in life. Currently, maternal obesity is a …

In brief Developmental programming refers to the long-term programming of gene
expression during fetal and postnatal development, resulting in altered organ function even …

Maternal obesity has become a worldwide epidemic. Obesity and a high-fat diet have been
shown to have deleterious effects on fetal programming, predisposing offspring to adverse …

Nonalcoholic fatty liver disease (NAFLD) is the main liver disease worldwide, and its
prevalence in children and adolescents has been increasing in the past years. It has been …

This review article outlines epidemiologic studies that support the hypothesis that maternal
environment (including early nutrition) plays a seminal role in determining the offspring's …

Gastric inhibitory polypeptide receptor (GIPR) directly induces energy accumulation in
adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on …