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Understanding and targeting resistance mechanisms in cancer
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …
practice, which is one of the major causes of treatment failure and poor patient survival. The …
Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
JM Mulcahy Levy, A Thorburn - Cell Death & Differentiation, 2020 - nature.com
Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …
in basal or stress-induced turnover of cell components that provide energy and …
Targeting autophagy in cancer
JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …
degradation, leading to the basal turnover of cell components and providing energy and …
Targeting autophagy in cancer
AV Onorati, M Dyczynski, R Ojha, RK Amaravadi - Cancer, 2018 - Wiley Online Library
Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular
homeostasis during stress conditions. Dysregulated autophagy has implications in health …
homeostasis during stress conditions. Dysregulated autophagy has implications in health …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin… - Autophagy, 2016 - escholarship.org
Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …
essential for demonstrating autophagy, either for the purposes of their own research, or in …
Autophagy, cancer stem cells and drug resistance
AG Smith, KF Macleod - The Journal of pathology, 2019 - Wiley Online Library
Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …
Recent insights into the function of autophagy in cancer
R Amaravadi, AC Kimmelman, E White - Genes & development, 2016 - genesdev.cshlp.org
Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines
JL Chen, X Wu, D Yin, XH Jia, X Chen, ZY Gu… - Pharmacology & …, 2023 - Elsevier
Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …
Natural products: An upcoming therapeutic approach to cancer
S Dutta, S Mahalanobish, S Saha, S Ghosh… - Food and Chemical …, 2019 - Elsevier
Cancer is one of the leading causes of death across the world. Different environmental and
anthropogenic factors initiate mutations in different functional genes of growth factors and …
anthropogenic factors initiate mutations in different functional genes of growth factors and …