Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The
transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Abstract Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer
leads to the emergence of resistant tumors characterized by lineage plasticity and …

Tissue regeneration declines with ageing but little is known about whether this arises from
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

FOXO transcription factors are conserved regulators of longevity downstream of insulin
signaling. These transcription factors integrate signals emanating from nutrient deprivation …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …