Plant serine protease inhibitors: biotechnology application in agriculture and molecular farming

M Clemente, MG Corigliano, SA Pariani… - International journal of …, 2019 - mdpi.com
The serine protease inhibitors (SPIs) are widely distributed in living organisms like bacteria,
fungi, plants, and humans. The main function of SPIs as protease enzymes is to regulate the …

Transgene expression in microalgae—from tools to applications

L Doron, N Segal, M Shapira - Frontiers in plant science, 2016 - frontiersin.org
Microalgae comprise a biodiverse group of photosynthetic organisms that reside in water
sources and sediments. The green microalgae Chlamydomonas reinhardtii was adopted as …

Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens

S Chaudhary, Z Ali, M Tehseen, EF Haney… - Nature …, 2023 - nature.com
Antimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to
combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and …

Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules

SA Wilson, SC Roberts - Plant biotechnology journal, 2012 - Wiley Online Library
Plant cell culture systems were initially explored for use in commercial synthesis of several
high‐value secondary metabolites, allowing for sustainable production that was not limited …

Plant molecular farming: much more than medicines

M Tschofen, D Knopp, E Hood… - Annual Review of …, 2016 - annualreviews.org
Plants have emerged as commercially relevant production systems for pharmaceutical and
nonpharmaceutical products. Currently, the commercially available nonpharmaceutical …

Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures

J Xu, X Ge, MC Dolan - Biotechnology advances, 2011 - Elsevier
“Molecular farming” in plants with significant advantages in cost and safety is touted as a
promising platform for the production of complex pharmaceutical proteins. While whole-plant …

Hairy root type plant in vitro systems as sources of bioactive substances

MI Georgiev, AI Pavlov, T Bley - Applied microbiology and biotechnology, 2007 - Springer
Abstract “Hairy root” systems, obtained by transforming plant tissues with the “natural genetic
engineer” Agrobacterium rhizogenes, have been known for more than three decades. To …

Production of heterologous proteins in plants: strategies for optimal expression

PN Desai, N Shrivastava, H Padh - Biotechnology advances, 2010 - Elsevier
Plants are a promising expression system for the production of heterologous proteins,
especially therapeutic proteins. Currently the majority of therapeutic proteins are produced …

Pharmaceutically active natural product synthesis and supply via plant cell culture technology

ME Kolewe, V Gaurav, SC Roberts - Molecular pharmaceutics, 2008 - ACS Publications
The chemical diversity of plant-derived natural products allows them to function in a
multitude of ways including flavor enhancers, agricultural chemicals, and importantly, human …

Viral vectors for production of recombinant proteins in plants

C Lico, Q Chen, L Santi - Journal of cellular physiology, 2008 - Wiley Online Library
Global demand for recombinant proteins has steadily accelerated for the last 20 years.
These recombinant proteins have a wide range of important applications, including vaccines …