Evaluation of xanthine oxidase inhibitor properties on isoindoline-1, 3-dion derivatives and calculation of interaction mechanism

Ö Gunduğdu, SAA Noma, T Taskin-Tok, B Ateş… - Journal of Molecular …, 2020 - Elsevier
The aim of the present study was to synthesis of isoindole-1, 3 (2H)-dione (Phthalimides)
derivatives and to investigation the inhibition of xanthine oxidase (XO). In study, xanthine …

Synthesis, spectroscopic characterization of novel phthalimides derivatives bearing a 1, 2, 3-triazole unit and examination as potential SARS-CoV-2 inhibitors via in …

A Tan - Journal of Molecular Structure, 2022 - Elsevier
In the present study, novel phthalimide derivatives 8 (af) and 9 (af) bearing a 1, 2, 3-triazole
subunit were synthesized via CuAAC reactions and characterized by 1 H, 13 C NMR, HR …

Evaluation of cytotoxic potentials of some isoindole-1, 3-dione derivatives on HeLa, C6 and A549 cancer cell lines

A Tan, AS Yaglioglu, NH Kishali, E Sahin… - Medicinal …, 2020 - ingentaconnect.com
Background: Norcantharimides are known as norcantharidine derivatives and contain an
isoindole skeleton structure. Isoindole derivatives have positive effect on inflammatory …

[HTML][HTML] A flow reactor setup for photochemistry of biphasic gas/liquid reactions

J Schachtner, P Bayer… - Beilstein Journal of …, 2016 - beilstein-journals.org
A home-built microreactor system for light-mediated biphasic gas/liquid reactions was
assembled from simple commercial components. This paper describes in full detail the …

Reduction of 2-phenyl-3a, 4, 7, 7a-tetrahydro-1H-isoindole-1, 3 (2H)-dione with NaBH4: Investigation of exo-selectivity and reaction mechanism via theoretical …

Ö Gündoğdu, A Atalay, P Turhan, B Anıl, E Şahin… - Journal of Molecular …, 2025 - Elsevier
The reaction of the bicyclic imide with NaBH 4 afforded acylaminocarbinol and carboxamide
derivatives. The exact configuration of acylaminocarbinol 7 was determined by X-ray crystal …

Evaluation of isoindole derivatives: Antioxidant potential and cytotoxicity in the HT‐29 colon cancer cells

A Kılıç Süloğlu, G Selmanoglu… - Archiv der …, 2020 - Wiley Online Library
Norcantharimides have an isoindole skeleton structure, and some isoindoline derivatives
have positive effects on inflammatory pathologies, including cancers. The present study …

Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration

HG Keceli, C Bayram, E Celik, N Ercan… - Journal of …, 2020 - Wiley Online Library
Objective To test the surface properties and in vitro effects of a new sequential release
system on MC3T3‐E1 cells for improved osseointegration. Background BMP6‐loaded …

Synthesis and anticancer activity evaluation of new isoindole analogues

A Köse, Y Bal, NH Kishalı, G Şanlı-Mohamed… - Medicinal Chemistry …, 2017 - Springer
We have developed a versatile synthetic approach for the synthesis of new isoindole
derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo …

A phthalimide-based fluorescent probe for thiophenol detection in water samples and living cells with a large Stokes shift

X Liu, L Yang, L Gao, W Chen, F Qi, X Song - Tetrahedron, 2015 - Elsevier
A phthalimide-based fluorescent probe for the detection of thiophenol was developed based
on the combination of photo-induced electron transfer (PET) and excited-state …

Synthesis, investigation of the cholinesterase inhibitory activities and in silico studies of some novel N-substituted phthalimide derivatives

A Tan, Z Almaz - Journal of the Iranian Chemical Society, 2022 - Springer
Novel N-substituted phthalimide derivatives (4a–c) were synthesized using a three-step
procedure in high yields. The inhibitory effects of these compounds against Electric eel …