Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding
motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had …

A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the
envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif …

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year
survival of< 10% because of diffuse symptoms leading to late-stage diagnosis. That survival …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Rationale: The evidence supporting an association between traffic-related air pollution
exposure and incident childhood asthma is inconsistent and may depend on genetic factors …

Leveraging the conserved cancer genomes across mammals has the potential to transform
driver gene discovery in orphan cancers. Here, we combine cross-species genomics with …

A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human
papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid …

Herpesviruses are ubiquitous in the human population and they extensively remodel the
cellular environment during infection. Multiplexed quantitative proteomic analysis over the …

Cell signaling pathways are the mechanisms by which cells transduce external stimuli,
which control the transcription of genes, to regulate diverse biological effects. In cancer …