Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

Hemophilia A (HA) and hemophilia B (HB) are the most common severe bleeding disorders.
Replacement therapy, providing the missing coagulation factor, has been the mainstay of …

Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …

Despite their rarity and structural complexity, natural and synthetic biscoumarins have
polarized much attention from investigators particularly due to their characteristic activity as …

Protein S is a critical regulator of coagulation that functions as a cofactor for the activated
protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct …

Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification,
which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is …

Background Bronchial asthma is a chronic disease characterized by inflammation,
obstruction, and hyperresponsiveness of the airways. There is currently no curative therapy …

Hereditary deficiencies of protein S (PS) increase the risk of venous thrombosis; however,
assessing the plasma levels of PS can be difficult because of its complex physiological …

The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6
(GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of …

Two complex protein defense systems—complement and coagulation—are based on
amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of …