Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain
The study of sex differences in the brain is a topic of neuroscientific study that has broad
reaching implications for culture, society and biomedical science. Recent research in rodent …
reaching implications for culture, society and biomedical science. Recent research in rodent …
Microglia in CNS development: Sha** the brain for the future
Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …
mainly known for their roles in neuropathologies. However, major recent developments have …
A starring role for microglia in brain sex differences
Microglia, the resident innate immune cells in the brain, have long been understood to be
crucial to maintenance in the nervous system, by clearing debris, monitoring for infiltration of …
crucial to maintenance in the nervous system, by clearing debris, monitoring for infiltration of …
The prostanoid EP4 receptor and its signaling pathway
The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …
Convergence of sex differences and the neuroimmune system in autism spectrum disorder
The male bias in autism spectrum disorder incidence is among the most extreme of all
neuropsychiatric disorders, yet the origins of the sex difference remain obscure …
neuropsychiatric disorders, yet the origins of the sex difference remain obscure …
Neural control of sexually dimorphic social behavior: Connecting development to adulthood
Rapid advances in the neural control of social behavior highlight the role of interconnected
nodes engaged in differential information processing to generate behavior. Many innate …
nodes engaged in differential information processing to generate behavior. Many innate …
Surprising origins of sex differences in the brain
This article is part of a Special Issue “SBN 2014”. Discerning the biologic origins of
neuroanatomical sex differences has been of interest since they were first reported in the …
neuroanatomical sex differences has been of interest since they were first reported in the …
Sexual differentiation of the rodent brain: dogma and beyond
Steroid hormones of gonadal origin act on the neonatal brain to produce sex differences that
underlie adult reproductive physiology and behavior. Neuronal sex differences occur on a …
underlie adult reproductive physiology and behavior. Neuronal sex differences occur on a …
Mast cells in the develo** brain determine adult sexual behavior
Many sex differences in brain and behavior are programmed during development by
gonadal hormones, but the cellular mechanisms are incompletely understood. We found that …
gonadal hormones, but the cellular mechanisms are incompletely understood. We found that …
A new view of sexual differentiation of mammalian brain
Establishment of enduring sex differences in brain and behavior occurs during pre-or
perinatal development, depending on species. For over 50 years the focus has been on …
perinatal development, depending on species. For over 50 years the focus has been on …