Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …

The efficacy of drugs widely varies in individuals, and the gut microbiota plays an important
role in this variability. The commensal microbiota living in the human gut encodes several …

Maternal obesity has been reported to be related to neurodevelopmental disorders in the
offspring. However, the underlying mechanisms and effective interventions remain unclear …

Nonsteroidal anti-inflammatory drugs (NSAID) s relieve pain, inflammation, and fever by
inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical …

The composition of intestinal microbiota is influenced by a number of factors, including
medications, which may have a substantial impact on host physiology. Nonsteroidal anti …

The human gut microbiota has been the interest of extensive research in recent years and
our knowledge on using the potential capacity of these microbes are growing rapidly …

Macrophages (Mϕs) are known to be major producers of the anti-inflammatory cytokine
interleukin-10 (IL-10) in the intestine, thus playing an important role in maintaining …

As a class of the commonly used drugs in clinical practice, non-steroidal anti-inflammatory
drugs (NSAIDs) can cause a series of adverse events including gastrointestinal injuries …

Abstract Inflammatory Bowel Diseases (IBD) are chronic inflammatory conditions of the
intestinal tract. IBD are believed to result from an inappropriate immune response against …

The human microbiome contains a vast source of genetic and biochemical variation, and its
impacts on therapeutic responses are just beginning to be understood. This expanded …