OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes
(T2D) results from inadequate β cell mass and function that can no longer compensate for …

Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell
failure in diabetes. However, the molecular mechanisms that underlie the loss of beta cell …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Understanding the biology underlying the mechanisms and pathways regulating pancreatic
β cell development is necessary to understand the pathology of diabetes mellitus (DM) …

A major goal in diabetes research is to find ways to enhance the mass and function of insulin
secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even …

Maturity-onset diabetes of the young (MODY) is a subtype of diabetes defined by an
autosomal pattern of inheritance and a young age at onset, often before age 25. MODY is …

Glucose stimulates rodent and human β-cell replication, but the intracellular signaling
mechanisms are poorly understood. Carbohydrate response element-binding protein …

The identification of factors that promote β cell proliferation could ultimately move type 1
diabetes treatment away from insulin injection therapy and toward a cure. We have …

Loss of functional β-cell mass is a hallmark of type 1 and type 2 diabetes, and methods for
restoring these cells are needed. We have previously reported that overexpression of the …