Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …
system and are the first line of host defense against microbial pathogens by recognizing …
[HTML][HTML] The good and the bad: monocytes' and macrophages' diverse functions in inflammation
J Austermann, J Roth, K Barczyk-Kahlert - Cells, 2022 - mdpi.com
Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …
[HTML][HTML] The role of microRNAs in inflammation
Inflammation is a biological response of the immune system to various insults, such as
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …
pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro …
Cell type-specific roles of NF-κB linking inflammation and thrombosis
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
Transition from inflammation to proliferation: a critical step during wound healing
The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …
Resolution of inflammation: a new therapeutic frontier
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …
The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …
[HTML][HTML] Exosome-derived microRNAs of human milk and their effects on infant health and development
BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
Molecular mechanisms that influence the macrophage M1–M2 polarization balance
N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …