Mice engrafted with human liver cells

YP de Jong - Seminars in liver disease, 2024 - thieme-connect.com
Rodents are commonly employed to model human liver conditions, although species
differences can restrict their translational relevance. To overcome some of these limitations …

Treatment induced clearance of hepatitis E viruses by interferon‐lambda in liver‐humanized mice

G Sari, CE Mulders, J Zhu, GW van Oord… - Liver …, 2021 - Wiley Online Library
Abstract Background Hepatitis E viruses (HEV) are an underestimated global cause of
enterically transmitted viral hepatitis, which may persist in immunocompromised hosts …

The viral ORF3 protein is required for hepatitis E virus apical release and efficient growth in polarized hepatocytes and humanized mice

G Sari, J Zhu, C Ambardekar, X Yin, A Boonstra… - Journal of …, 2021 - Am Soc Microbiol
Hepatitis E virus (HEV), an enterically transmitted RNA virus, is a major cause of acute
hepatitis worldwide. Additionally, HEV genotype 3 (gt3) can frequently persist in …