The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility
preservation option for young women. The only available option to restore fertility using this …

Considerable challenges in engineering the female reproductive tissue are the follicle's
unique architecture, the need to recapitulate the extracellular matrix, and tissue …

Chemo-and radiation therapies used to treat cancer can have the unintended effect of
making patients infertile. Clinically established fertility preservation methods, such as egg …

Synthetic matrices which mimic the extracellular composition of native tissue create a
comprehensive model for studying development and disease. Here, we have engineered a …

Abstract Information for organismal patterning can come from a variety of sources. We
investigate the possibility that instructive influences for normal embryonic development are …

The ovarian follicle is the structural and functional unit of the ovary, composed of the female
gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a …