Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Introduction Breast cancer is the most common cancer and the second leading cause of
cancer-related death in women worldwide. Despite the early detection of breast cancer and …

Stromal communication with cancer cells can influence treatment response. We show that
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …

Breast cancer stem cells (CSCs) are thought to drive recurrence and metastasis. Their
identity has been linked to the epithelial to mesenchymal transition (EMT) but remains highly …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

The Notch signalling pathway is a highly conserved developmental signalling pathway, with
vital roles in determining cell fate during embryonic development and tissue homeostasis …

Breast cancer represents a highly heterogeneous disease comprised by several subtypes
with distinct histological features, underlying molecular etiology and clinical behaviors. It is …

Intercellular communication plays an important role in cancer initiation and progression
through secretory molecules, including growth factors and cytokines. Recent advances have …

Tumours are comprised of a highly heterogeneous population of cells, of which only a small
subset of stem-like cells possess the ability to regenerate tumours in vivo. These cancer …

Purpose: Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed
metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are …