Melatonin as an antioxidant: under promises but over delivers

RJ Reiter, JC Mayo, DX Tan, RM Sainz… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Insight into melatonin-mediated response and signaling in the regulation of plant defense under biotic stress

RK Tiwari, MK Lal, R Kumar, V Mangal, MA Altaf… - Plant molecular …, 2021 - Springer
Key message Melatonin plays a crucial role in the mitigation of plant biotic stress through
induced defense responses and pathogen attenuation. Utilizing the current knowledge of …

Emerging roles of melatonin in mitigating abiotic and biotic stresses of horticultural crops

RK Tiwari, MK Lal, KC Naga, R Kumar… - Scientia …, 2020 - Elsevier
Environmental stress and pathogen infection are the major limiting factors in worldwide
horticulture production, resulting in huge yield loss. Melatonin (N-acetyl-5 …

Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

HM Zhang, Y Zhang - Journal of pineal research, 2014 - Wiley Online Library
Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Melatonin attenuates potato late blight by disrupting cell growth, stress tolerance, fungicide susceptibility and homeostasis of gene expression in Phytophthora …

S Zhang, X Zheng, RJ Reiter, S Feng, Y Wang… - Frontiers in plant …, 2017 - frontiersin.org
Phytophthora infestans (P. infestans) is the causal agent of potato late blight, which caused
the devastating Irish Potato Famine during 1845-1852. Until now, potato late blight is still the …

Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease

DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

Synergistic anti‐oomycete effect of melatonin with a biofungicide against oomycetic black shank disease

S Zhang, S Liu, J Zhang, RJ Reiter… - Journal of Pineal …, 2018 - Wiley Online Library
Human health, food safety, and agriculture have been threatened by oomycetic diseases
caused by notorious pathogenic oomycetes. Chemical oomyceticides are the main …

Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism

MF Laranjeira‐Silva, RA Zampieri… - Journal of Pineal …, 2015 - Wiley Online Library
Acute inflammatory responses induced by bacteria or fungi block nocturnal melatonin
synthesis by rodent pineal glands. Here, we show Leishmania infection does not impair …

Melatonin enhances the mitochondrial functionality of brown adipose tissue in obese—Diabetic rats

A Agil, M Navarro-Alarcon, FAZ Ali, A Albrakati… - Antioxidants, 2021 - mdpi.com
Develo** novel drugs/targets remains a major effort toward controlling obesity-related
type 2 diabetes (diabesity). Melatonin controls obesity and improves glucose homeostasis in …

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

JCR Fernandes, JI Aoki, S Maia Acuña… - Frontiers in Cellular …, 2019 - frontiersin.org
Leishmaniases are neglected diseases that cause a large spectrum of clinical
manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory …