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Epigenetic modifications: basic mechanisms and role in cardiovascular disease
The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …
and the environment that are involved in development and differentiation in higher …
Non‐coding RNAs: regulators of disease
For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
TB Hansen, ED Wiklund, JB Bramsen… - The EMBO …, 2011 - embopress.org
MicroRNAs (miRNAs) are∼ 22 nt non‐coding RNAs that typically bind to the 3′ UTR of
target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational …
target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational …
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic
S Broder - Antiviral research, 2010 - Elsevier
In the last 25 years, HIV-1, the retrovirus responsible for the acquired immunodeficiency
syndrome (AIDS), has gone from being an “inherently untreatable” infectious agent to one …
syndrome (AIDS), has gone from being an “inherently untreatable” infectious agent to one …
Regulation of mammalian DNA methyltransferases: a route to new mechanisms
H Denis, MN Ndlovu, F Fuks - EMBO reports, 2011 - embopress.org
DNA methyltransferases (DNMTs) establish and maintain DNA methylation patterns at
specific regions of the genome, thereby contributing to gene regulation. It is becoming …
specific regions of the genome, thereby contributing to gene regulation. It is becoming …
Novel classes of non-coding RNAs and cancer
J Sana, P Faltejskova, M Svoboda, O Slaby - Journal of translational …, 2012 - Springer
For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein …
mainly as an informational intermediate between a DNA sequence and its encoded protein …
A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs
A Sadakierska-Chudy, M Filip - Neurotoxicity research, 2015 - Springer
The complexity of the genome is regulated by epigenetic mechanisms, which act on the
level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various …
level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various …
[HTML][HTML] Non-coding RNAs: multi-tasking molecules in the cell
In the last years it has become increasingly clear that the mammalian transcriptome is highly
complex and includes a large number of small non-coding RNAs (sncRNAs) and long …
complex and includes a large number of small non-coding RNAs (sncRNAs) and long …
Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse …
While several studies have focused on the relationship between individual miRNA loci or
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
The redox basis of epigenetic modifications: from mechanisms to functional consequences
Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …