Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and
physiologically relevant ex vivo model for studying the intricacies of lung diseases, including …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine and exerts its complex biological
functions mainly through three different signal modes, called cis-, trans-, and cluster …

Fibrogenesis is part of a normal protective response to tissue injury that can become
irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), a
transformation product of tyre-derived 6-PPD, has been frequently detected in different …

The long-term physiological consequences of respiratory viral infections, particularly in the
aftermath of the COVID-19 pandemic—termed post-acute sequelae of SARS-CoV-2 (PASC) …

Background Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is
pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with high mortality. The
Food and Drug Administration-approved drugs, nintedanib and pirfenidone, could delay …

Cell collectives must dynamically adapt to different biological contexts. For instance, in
homeostatic conditions, epithelia must establish a barrier between body compartments and …

SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance
inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts …

The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the
assumption that the structures under study will perform at the best in vitro if cultivated in an …