Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Z Chen, F Han, Y Du, H Shi, W Zhou - Signal transduction and targeted …, 2023‏ - nature.com
Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

The effect of HIF on metabolism and immunity

CT Taylor, CC Scholz - Nature Reviews Nephrology, 2022‏ - nature.com
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

X Zhong, X He, Y Wang, Z Hu, H Huang, S Zhao… - Journal of hematology & …, 2022‏ - Springer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Crosstalk between glucose metabolism, lactate production and immune response modulation

L Ye, Y Jiang, M Zhang - Cytokine & Growth Factor Reviews, 2022‏ - Elsevier
Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

[HTML][HTML] Photodynamic therapy combined with immunotherapy: Recent advances and future research directions

M Warszyńska, P Repetowski, JM Dąbrowski - Coordination Chemistry …, 2023‏ - Elsevier
Innovative anticancer therapies based on the activation of the immune system offer promise
in the battle against cancers resistant to traditional treatments. Examples of such therapeutic …

Metabolism of immune cells in cancer

RD Leone, JD Powell - Nature reviews cancer, 2020‏ - nature.com
Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …

An HIF-1α/VEGF-A axis in cytotoxic T cells regulates tumor progression

A Palazon, PA Tyrakis, D Macias, P Veliça… - Cancer cell, 2017‏ - cell.com
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during
adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF …

Immunometabolism governs dendritic cell and macrophage function

LAJ O'Neill, EJ Pearce - Journal of Experimental Medicine, 2016‏ - rupress.org
© 2016 O'Neill and Pearce This article is distributed under the terms of an Attribution–
Noncommercial–Share Alike–No Mirror Sites license for the first six months after the …

Coupling Krebs cycle metabolites to signalling in immunity and cancer

DG Ryan, MP Murphy, C Frezza, HA Prag… - Nature …, 2019‏ - nature.com
Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

HIF1α and metabolic reprogramming in inflammation

SE Corcoran, LAJ O'Neill - The Journal of clinical investigation, 2016‏ - jci.org
HIF1α is a common component of pathways involved in the control of cellular metabolism
and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for …