The development of new and effective therapeutics is reliant on the ability to study the
underlying mechanisms of potential drug targets in live cells and multicellular systems. A …

Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

Genetic changes are difficult to reverse; thus, epigenetic aberrations, including changes in
DNA methylation, histone modifications, and noncoding RNAs, with potential reversibility …

Optochemical tools have become potent instruments for understanding biological processes
at the molecular level, and the past decade has witnessed their use in epigenetics and …

Histone deacetylases (HDACs) play crucial roles in the epigenetic regulation of gene
expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically …

We report the synthesis and biological evaluation of a light‐activated (caged) prodrug of the
KDAC inhibitor panobinostat (Zap‐Pano). We demonstrate that addition of the 4, 5 …

Abstract Purpose The Lumi-Solve photo-angioplasty drug eluting balloon catheter (DEBc)
may afford safety advantages over current DEBc. Lumi-Solve utilises the guidewire (GW) …

Purpose Paclitaxel (PTX)-coated drug eluting balloon catheters (DEBc) used in the
management of neointimal hyperplasia (NIH) have been associated with safety concerns …

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