COPD and gut–lung axis: how microbiota and host Inflammasome influence COPD and related therapeutics

L Qu, Q Cheng, Y Wang, H Mu, Y Zhang - Frontiers in Microbiology, 2022 - frontiersin.org
The exact pathogenesis of chronic obstructive pulmonary disease (COPD) remains largely
unknown. While current management strategies are effective at stabilizing the disease or …

The role of NLRP3 inflammasome in colorectal cancer: Potential therapeutic target

S Vafaei, H Taheri, Y Hajimomeni… - Clinical and …, 2022 - Springer
All phases of carcinogenesis are affected by inflammation. Activation of the inflammasome is
a crucial signaling mechanism that leads to acute and chronic inflammation. When specific …

Oryzanol ameliorates DSS-stimulated gut barrier damage via targeting the gut microbiota accompanied by the TLR4/NF-κB/NLRP3 cascade response in vivo

X **a, H Lin, F Luo, X Wu, L Zhu, S Chen… - Journal of Agricultural …, 2022 - ACS Publications
Inflammatory bowel disease (IBD) is a global chronic disease with a long duration and
repeated relapse. Currently, there is still a lack of effective approaches to prevent IBD. Food …

Avenanthramide C from oats protects pyroptosis through dependent ROS-induced mitochondrial damage by PI3K ubiquitination and phosphorylation in pediatric …

Z Pu, C Shen, W Zhang, H **e… - Journal of Agricultural and …, 2022 - ACS Publications
Oat containing rich β-glucan, polyphenols, flavonoids, saponins, alkaloids, and other
substances shows good biological activities. Therefore, the present study aimed to uncover …

Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection

YJ Kim, JY Lee, JJ Lee, SM Jeon, P Silwal, IS Kim… - Gut …, 2022 - Taylor & Francis
Nontuberculous mycobacterial pulmonary diseases (NTM-PDs) are emerging as global
health threats with issues of antibiotic resistance. Accumulating evidence suggests that the …

Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice

N Yang, T Lan, Y Han, H Zhao, C Wang, Z Xu, Z Chen… - PLoS …, 2023 - journals.plos.org
Tributyrin (TB) is a butyric acid precursor and has a key role in anti-inflammatory and
intestinal barrier repair effects by slowly releasing butyric acid. However, its roles in gut …

Intestinal microbiota-an unmissable bridge to severe acute pancreatitis-associated acute lung injury

Z Wang, F Li, J Liu, Y Luo, H Guo, Q Yang… - Frontiers in …, 2022 - frontiersin.org
Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general
surgery, is characterized by acute and rapid onset as well as high mortality, which often …

Heme oxygenase-1 ameliorates endotoxin-induced acute lung injury by modulating macrophage polarization via inhibiting TXNIP/NLRP3 inflammasome activation

X Wu, L Wu, Y Wu, W Chen, J Chen, L Gong… - Free Radical Biology and …, 2023 - Elsevier
Acute lung injury (ALI) remains a global public health issue without specific and effective
treatment options available in the clinic. Alveolar macrophage polarization is involved in the …

[HTML][HTML] PM2. 5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis

L Zhao, B Li, L Zhou, C Song, T Kang, Y Xu… - Ecotoxicology and …, 2023 - Elsevier
Children are disproportionately represented among those who suffer asthma, which is a kind
of chronic airway inflammation. Asthma symptoms might worsen when exposed to the air …

Emerging insights into the impact of air pollution on immune-mediated asthma pathogenesis

JA Tuazon, B Kilburg-Basnyat, LM Oldfield… - Current allergy and …, 2022 - Springer
Abstract Purpose of Review Increases in ambient levels of air pollutants have been linked to
lung inflammation and remodeling, processes that lead to the development and …